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About Alzheimer's & Dementia

Cause & cure Research on the cause of dementia

Video: Info on reversible vs. non-reversible causes of dementia

Video: Info on reversible vs. non-reversible causes of dementia

Research on the cause of dementia

Research has shown that the major forms of dementia are characterized by an excess in the brain of certain proteins or protein fragments that have taken abnormal forms thought to be toxic to brain cells. Some of these protein abnormalities can be detected in cerebrospinal fluid. For example, an abnormally high accumulation of beta-amyloid protein in the brain is a hallmark of Alzheimer’s Disease (AD).
In Frontotemporal Dementia (FTD), AD, and other neurodegenerative diseases, the protein tau collects in abnormal tangled masses of filaments that disrupt nerve signaling, causing cell death and impairing cognition. Similarly, the abnormal accumulation of the protein alpha-synuclein is a hallmark of Parkinson’s disease and Lewy body dementia.
 
Source: Types of dementia and causes

Source: Dementias, hope through research

BLOCKING BRAIN INFLAMMATION COULD PROTECT AGAINST MEMORY LOSS IN ALZHEIMER’S DISEASE

A new study discovered that blocking a receptor in the brain that regulates immune cells could prevent some changes to memory and behaviour observed in Alzheimer’s disease. This study adds to evidence that inflammation in the brain plays a role in the development of Alzheimer’s disease and proposes that by reducing this inflammation, disease progression may be delayed. Researchers at the University of Southampton used post-mortem brain tissue samples to show that a greater amount of an immune cell, called microglia is present in the brains of people with Alzheimer’s disease compared to the brains of healthy people. Using mouse models of Alzheimer’s disease, the researchers prevented the production of microglia in the brain and were able to decrease memory loss. The mice were given a drug that inhibits a receptor called CSF1R, which is involved in the regulation of microglia. “This study shows that the production of new immune cells in the Alzheimer's brain contributes to the development of memory impairments - and that by blocking this immune reaction memory loss can be reduced. 

Source: Alzheimer’s Society London, January 8, 2016. 

Preventing Diabetes may help halt Alzheimer’s Progression

“Unprevented Diabetes Means Unnecessary Alzheimer’s,” so says a new statement issued by Health People: Community Preventive Health Institute. Doctors say diabetes increases the risk of getting Alzheimer’s by 40 percent. Preventive measures that focus on improvements in diet and exercise can halt the progression from pre-diabetes to full disease.

National Diabetes Prevention Program is a multi-session course approved by the Centers for Disease Control and Prevention. The program helps people who already have high blood sugar reduce their chances of converting to diabetes by almost 60 percent — which also slashes their risk of Alzheimer’s.

Preventing even a small conversion of pre-diabetes to diabetes would in turn result significant decrease in the number of new cases of dementia.

Source: alzheimersnewstoday.com, May 16 2017

Video: Info on reversible vs. non-reversible causes of dementia